TNF-α (Tumor Necrosis Factor-alpha) is a pro-inflammatory cytokine, a protein produced by the immune system. It plays a major role in inflammation and immune system regulation.

Elevated levels of TNF-α are often associated with chronic inflammation, autoimmune disorders, and certain cancers.

Why is the TNF-α Test Done?

✅ To detect and monitor chronic inflammatory conditions, such as:

• Rheumatoid Arthritis (RA)

• Inflammatory Bowel Disease (IBD) – Crohn’s disease, Ulcerative colitis

• Psoriasis

• Systemic Lupus Erythematosus (SLE)

• Ankylosing Spondylitis

• Sepsis and infections

• Certain cancers and cachexia

✅ To assess response to anti-TNF therapy (biologics like infliximab, etanercept)